Lunch 'n Learn presentation: We have begun to develop an understanding of what makes computational tasks "intractable" not just for current computers but for all foreseeable computers. This has implications for many scientific fields. An overview of the field and the research center headquartered at Princeton. More information available at http://blogs.princeton.edu/itsacademic/2008/12/computational_intractability_a_barrier_for_computers_man_and_science.html.